Hepatoprotective Effects of Kombucha Tea and Silymarin Against Thioacetamide Induced Liver Toxicity in Rats

Abstract

Background and Objectives: Silybum marianum and Kombucha tea contain thousands of antioxidant compounds, which known as a drug, used for hepatoprotective agent. Liver exposes to many of oxidant and carcinogen agents; therefore; the antioxidant compounds are beneficial for its natural health. In this study the hepatoprotective effects of silymarin and Kombucha tea against Thioacetamide (TAA) induced liver toxicity in wistar rats were investigated and compared. Materials and Methods: In this experimental study we used 35 male white wistar rats and they were categorized into seven groups: (I), treated with thioacetamide (TAA) for 3 weeks (II), treated with TAA and silymarin (400mg/kg) (for 3 weeks)(III), treated with silymarin (400mg/kg) then were treatment TAA (for 3 weeks)(IV), treated with TAA and silymarin (200mg/kg) (for 3 weeks)(V), treated with TAA and Kombucha tea (50mg/kg) (for 3 weeks), treated with TAA, silymarin and Kombucha tea (for 3 weeks). Results: TAA significantly has increase Aspartate aminotransferase (AST), Alanine Transaminase (ALT), Alkaline Phosphatase (ALP), Lactate Dehydrogenase (LDH) but not the same for bilirubin. The treatment by silymarin and Kombucha tea produced a significant reduction in serum enzyme levels (AST, ALT, ALP, LDH) and reduction in bilirubin content. Conclusion: The results show that the protective effects of silymarin and Kombucha tea against the thioacetamide induced hepatotoxicity that may be due to the existence of polyphenol substances in the plants, these substances have an antioxidant function.

Keywords: Hepatoprotective, Thioacetamide, Silymarin, Kombucha tea, Rat