Logo-mj
Med J Tabriz Uni Med Sciences Health Services. 2014;36(3): 44-51.
  Abstract View: 201
  PDF Download: 43

Original Article

The Effect of Hydroalcoholic Extract of Nasturtium Officinale R.Br on Antioxidant Status and DNA Damage in Liver and Kidney Rats Exposed to Arsenic

Felor Zargari 1*, Amir Ghorbanihaghjo 2, Hossein Babaei 3, Safar Farajnia 4, Nasim Hayati Roodbari 1

1 Department of Biology Science and Research Branch, Islamic Azad University, Tehran, Iran
2 Department of Clinical Biochemistry, Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
3 Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
4 Department of Biotechnology, Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

Abstract

Background and Objectives: Oxidative stress has been implicated in various pathological consequences including such as cardiovascular disease , cancer, diabetes and aging. The present study investigated the effects of hydroalcoholic extract of Nasturtium Officinale on antioxidant status and DNA damage in arsenic –induced oxidative damage in liver and kidney tissue. Materials and Methods: In this experimental study ,48 male rats were selected and randomly divided into 6 groups: Group 1: normal healthy rat, group II was treated with sodium arsenite (SA) {i.p. injection at dose of 5.5 mg/kg body weight }, group III and group IV was treated with hydroalcoholic extract of N.Officinale (via gavage) at a dose of 200 and 500 mg/kg body weight respectively , group V and group VI was treated with hydroalcoholic extract of N.Officinale (via gavage) at a dose of 200 and 500 mg/kg body weight respectively + SA. Blood samples were collected and then examined antioxidant enzymes: Catalase (CAT), Superoxiddismutase (SOD) and Glutathion Peroxidase (GPx) activities, MDA (Malondialdehyde) content, 8-OHdG concentration in liver and kidney. Results: Results of current study indicates that N.Officinale consumption significantly increased the activities of antioxidant enzymes and decreased MDA content, 8-OHdG(8-hydroxydeoxyguanosine) Concentration in liver. The consumption of plant extract significantly increased the activity of GPx in kidney. Conclusions: N.Officinale (Watercress) reduces the arsenic-induced oxidative damage in liver and it has the little protective effect in kidney.
Keywords: Oxidative Stress, Nasturtium.Officinale R.Br, Antioxidant Enzymes, DNA Oxidative Damage
First Name
 
Last Name
 
Email Address
 
Comments
 
Security code


Abstract View: 202

Your browser does not support the canvas element.


PDF Download: 43

Your browser does not support the canvas element.

Submitted: 17 Jun 2013
Accepted: 05 Aug 2013
ePublished: 27 Aug 2014
EndNote EndNote

(Enw Format - Win & Mac)

BibTeX BibTeX

(Bib Format - Win & Mac)

Bookends Bookends

(Ris Format - Mac only)

EasyBib EasyBib

(Ris Format - Win & Mac)

Medlars Medlars

(Txt Format - Win & Mac)

Mendeley Web Mendeley Web
Mendeley Mendeley

(Ris Format - Win & Mac)

Papers Papers

(Ris Format - Win & Mac)

ProCite ProCite

(Ris Format - Win & Mac)

Reference Manager Reference Manager

(Ris Format - Win only)

Refworks Refworks

(Refworks Format - Win & Mac)

Zotero Zotero

(Ris Format - Firefox Plugin)