Study of PAI-1 -675 4G/5G Polymorphism among patients with breast cancer from North West of Iran

Abstract

Background: Previous studies have shown the association of genetic factors such as PAI-1 4G/5G polymorphism with susceptibility to breast cancer patients. The aim of this study was to investigate the effect of this polymorphism in breast cancer patients from North West of Iran. Methods: 160 breast cancer patients and 160 healthy individuals were selected. Peripheral blood-DNA samples were taken and used for PCR amplification using the allele specific primers. Results: Based on molecular studies, all patients and control group were divided into three genotypes 4G/4G, 4G/5G and 5G/5G. Genotype distribution between patients (11.25%, 71.25% and 17.50%, respectively) and controls (10.62%, 71.87% and 17.50%, respectively). Additionally, the frequencies of the 4G and 5G alleles between patients (46.87% and 53.12%, respectively) and control group (46.56% and 53.43%, respectively). Conclusion: The genotypic and allelic frequencies of PAI-1 4G/5G polymorphism showed no significant difference between breast cancer patients and control individuals in this cohort.