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Med J Tabriz Uni Med Sciences. 2023;45(5): 402-410.
doi: 10.34172/mj.2023.042
  Abstract View: 250
  PDF Download: 120

Endocrine System

Original Article

trans-Chalcone protects male rats against high-fat emulsion-induced pancreatic injury by inhibiting TNF-α and MCP-1 expression

Elham Karimi-Sales 1,2 ORCID logo, Mohammad Reza Alipour 3* ORCID logo

1 Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
2 Department of Physiology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
3 Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
*Corresponding Author: Email: alipourmr52@gmail.com

Abstract

Background. High-fat diet (HFD) intake is linked to ectopic fat deposition in the pancreas. It also causes pancreatic inflammatory lesions. trans-Chalcone is a simple chalcone with protective effects against HFD-induced metabolic disorders. This study, for the first time, explored the possible effects of this chalcone on high-fat emulsion-induced pancreatic abnormalities in rats.

Methods. Twenty-one male rats were randomly assigned into three groups: control (received 10% tween 80); HFD (received high-fat emulsion + 10% tween 80); and HFD + chalcone (received high-fat emulsion + trans-chalcone). Real-time PCR was used to assess pancreatic mRNA expression levels of monocyte chemoattractant protein-1 (MCP-1) and tumor necrosis factor α (TNF-α) in the pancreas of all rats.

Results. High-fat emulsion increased the mRNA expression levels of inflammatory biomarkers, including TNF-α and MCP-1 in the pancreas of rats, and treatment with trans-chalcone prevented these high-fat emulsion-induced changes.

Conclusion. trans-Chalcone can protect the pancreas of male rats against HFD-induced abnormalities through its anti-inflammatory effects.

Practical Implications. It seems that consumption of HFD up-regulates the production of inflammatory mediators in the pancreas. On the other hand, trans-chalcone can ameliorate HFD-related pancreatic inflammation.



How to cite this article: Karimi-Sales E, Alipour M R. trans-Chalcone protects male rats against high-fat emulsion-induced pancreatic injury by inhibiting TNF-α and MCP-1 expression. Med J Tabriz Uni Med Sciences. 2023;45():doi: 10.34172/mj.2023.042 Persian.
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Abstract View: 251

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Submitted: 11 Mar 2023
Revision: 09 May 2023
Accepted: 10 May 2023
ePublished: 11 Oct 2023
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