Med J Tabriz Uni Med Sciences. 2023;45(5): 411-424.
doi: 10.34172/mj.2023.043
  Abstract View: 380
  PDF Download: 113


Original Article

Comparing the efficacy of Bupropion and Ritaline on sexual dysfunction induced by Sertraline in women

Angela Hamidia 1 ORCID logo, Romina Hamzehpour 2 ORCID logo, Seyedeh Maryam Zavarmousavi 3 ORCID logo, Fahimeh Haghpanah 4 ORCID logo, Ali Bijani 1 ORCID logo, Armon Massoodi 1* ORCID logo

1 Psychiatry Social Determinants of Health Research Center, Babol University of Medical Sciences, Babol, Iran
2 Department of Psychiatry, Faculty of Medicine, Babol University of Medical Sciences, Babol, Iran
3 Department of Psychiatry, Shafa Hospital, Guilan University of Medical Sciences, Rasht, Iran
4 Student Research Committee, Babol University of Medical Sciences, Babol, Iran
*Corresponding Author: Email: armonmassoodi@gmail.com


Background. Sertraline is one of the most commonly used selective serotonin-reuptake inhibitors for patients with major depressive disorder. The prevalence of sexual dysfunction among patients who use selective serotonin-reuptake inhibitors is 40%–45% for women and 20%–30% for men. A strategy to prevent this side effect is combination therapy with medications such as buspiron and Ritalin. The aim of this study was to compare the effects of bupropion and Ritalin on sexual dysfunction among patients who use sertraline.

Methods. This single-blind randomized controlled trial was conducted in 2018. Fifty eligible women aged 20–45 years old were purposefully selected from the psychiatric clinics of Yahyanejad and Ruhani hospitals, Babol, Iran. Structured interview was used to screen participants for major depressive disorder, sertraline use, and sexual dysfunction. All participants completed the Arizona Sexual Experience Scale and were randomly allocated to the bupropion and the Ritalin group through block randomization. All participants re-completed the Scale one month after the intervention. Data were analyzed through SPSS software by repeated measure analysis of variance.

Results. All fifty participants (25 in each group) completed the study. The mean of participants’ age was 36.38±5.64 years and the mean score of their sexual dysfunction was 23.44±3.14 at pretest and 19.52±4.92 at posttest. Between-group differences respecting the mean scores of sexual dysfunction and all its items were insignificant both at pretest (P= 0.886) and posttest (P= 0.872). However, within-group comparisons revealed that the mean score of sexual dysfunction significantly decreased in both groups (P<0.001).

Conclusion. This study concludes the same efficacy of sustained release bupropion and Ritalin in significantly reducing sexual dysfunction among patients who used sertraline.

Practical Implications. According to the results of the present study and the similar efficacy of slow-release bupropion and Ritalin in improving sexual dysfunction caused by sertraline, it seems that Ritalin, due to its effectiveness in treatment, is an easier drug to use. It is more cost-effective and a better alternative to bupropion in improving sexual dysfunction in patients who are candidates for treatment with serotonin- reuptake inhibitors.

How to cite this article: Hamidia A, Hamzapour R, Zavarmosavi M, Haghpanah F, Bijani A, Massoodi A. Comparing the efficacy of Bupropion and Ritaline on Ssexual Ddysfunction induced by Sertraline in women. Med J Tabriz Uni Med Sciences. 2023;45(5):411-424. doi: 10.34172/mj.2023.043. Persian.
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Submitted: 20 Sep 2022
Accepted: 22 Apr 2023
ePublished: 15 Oct 2023
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