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Med J Tabriz Uni Med Sciences. 2022;44(3): 232-242.
doi: 10.34172/mj.2022.030

Scopus ID: 85137014086
  Abstract View: 410
  PDF Download: 161

Genetics

Original Article

Evaluation of miR-146a biomarker capability in mothers with recurrent miscarriage

Parisa Ostadhasanzadeh 1 ORCID logo, Jafar Mohseni 2* ORCID logo, Saeid Ghorbian 1, Sedigheh Abdollahi Fard 2, Changiz Ahmadizadeh 3

1 Department of Molecular Genetics, Faculty of Basic Sciences, Ahar Branch, Islamic Azad University, Ahar, Iran
2 Genetics Research Div, ART Center of ACECR East Azerbaijan Branch, East Azerbaijan ACECR, Tabriz, Iran
3 Department of Microbiology, Faculty of Basic Sciences, Ahar Branch, Islamic Azad University, Ahar, Iran
*Corresponding Author: Email: jmohseni46@gmail.com

Abstract

Background. If the pregnancy attempt fails, it may become a stressful event. Therefore, in many cases, problem solving can lead to greater satisfaction and cohesion of couples and prevent psychological and social harm to families. The aim of this study was to determine the significant difference in the expression of miR-146a miRNA in maternal blood between the control and observation groups and to determine whether the miRNA can be used as diagnostic biomarkers or not.

Methods. The present study is a basic and descriptive survey in terms of data analysis. The samples included pregnant women referred to Tabriz University of Jahad from September 2019 to February 2021. We used Exel, Spss v.21 and Roc software for data analysis. Data were prepared in Exel software with reference gene and by calculating CT. Were used in Roc software.

Results. The results showed a difference between the control and observation groups. Early detection of recurrent miscarriage should be used in these mothers.

Conclusion. Through using diagnostic kits of the studied miRNAs, effective steps can be taken for early detection, prevention of abortion, and reducing the heavy psychological, economic, and social burden on families. Therefore, it is suggested that diagnostic kits be made for these biomarkers and used in infertility centers.

Practical Implications. Among the practical implications of this study, we can mention the diagnosis and prevention of abortion, which can reduce the burden on families and society.



How to cite this article: Ostadhasanzadeh Maleki P, Mohseni J, ‪Ghorbian S, Abdollahi Fard S, Ahmadizadeh C. Med J Tabriz Uni Med Sciences. 2022; 44(3): doi: 10.34172/mj.2022.030. Persian.
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Submitted: 12 Feb 2022
Revision: 09 Jul 2022
Accepted: 09 Jul 2022
ePublished: 02 Aug 2022
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