Vitronectin, Serum Hs-CRP Levels and its association with the Extent and Severity of Coronary Artery Disease in Non-Smokers

Abstract

Background and Objectives: Coronary Artery Disease (CAD) Occurs as a result of atherosclerosis. There are several factors which are closely associated with CAD. Cell adhesion molecules such as Vitronectin (VN), could play an important role. The aim of the present study was to evaluate the VN and hs-CRP levels in a group of Non-Smokers with CAD and correlation with extent and Severity of CAD. Material and Methods: In this study 200 person included: (160 patient and 40 controls). Patients were divided based on angiographic findings in to 4 groups including: 40 individuals with no vessel disease, 40 individuals with single vessel disease, 40 individuals with double vessel disease and 40 individuals with triple vessel disease. The control group had no history of heart disease. Exclusion criteria were factors such as liver, kidney and lung diseases and malignancies. Serum levels of VN were determined by (ELISA) method (Glory Science) and serum concentration of hs-CRP was measured by Immunoturbidometric method. Results: The mean age of patient and controls were (58 ± 7 years and 56 ± 8). There was no significant difference between the two groups in their age and sex. Serum VN and hs-CRP levels in patient groups were significantly higher than control groups (p<0.05 for all). Moreover, serum levels of VN in patients with triple-vessel and one-vessel disease were significantly higher than control group (p<0.05 in all cases). Serum levels of hs-CRP in patient groups were significantly higher than controls (p<0.05). Conclusion: Serum levels of Vitronectin and hs-CRP were significantly higher in Non-Smoker CAD patients as in comparison with controls. Their association with the extent and severity of the lesion was present also.

Keywords: Vitronectin, Hs-CRP, Coronary Artery Disease, The extent and severity of disease, Non-Smoker