Logo-mj
Med J Tabriz Uni Med Sciences Health Services. 2013;35: 58-65.
  Abstract View: 239
  PDF Download: 30

Research

Renal Involvement in Different Genotypes of Familial Mediterranean Fever a report from Azerbaijan Province

Maryam Ghanbari 1, Mohammad Reza Ardalan 2*, Mortaza Jabbar Pour Bonyadi 3, Seyed Hesam Rahmani 4

1 Chronic Kidney Disease Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
2 Chronic Kidney Disease Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
3 Department of Molecular Genetic, School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
4 Department of Emergency Medicine, School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
*Corresponding Author: Email: ardalan34@yahoo.com

Abstract

Background and Objectives: Familial Mediterranean fever (FMF) is a hereditary disorder characterized by recurrent self-limited attacks of fever and polyserositis. The disease is associated with mutations in the (MEFV) gene. The M694V mutation carries a significant risk for amyloidosis. The purpose of this study was to evaluated renal involvement in different genotypes of familial Mediterranean fever among patients diagnosed in East Azerbaijan state. Material and Methods: Five hundred genetically identified FMF patients were included in our study and their demographic Characteristics, clinical manifestation and laboratory findings were studied respectively. According to their genotype and heterozygocity or homozygocity patients were divided into 4 groups (M694V/M694V, M694V/other, other/other, E148Q/other). Renal involvement defined by the presence of glomerular hematuria and persistent proteinuria unrelated to other conations. Results: Among our cohort we discovered nine patients (1.8%; M/F: 5/4) with renal involvement. Eight of them Kidney biopsy was performed and it was compatible with amyloidosis. One patient had acute glomerulonephritis with meningeal proliferation and these patients had E148Q mutation. The most frequent mutation among other patients was M694V (42%). Conclusion: The results of this study showed that in other ethnicities ‘like previously reported results M694V mutation is the most important genetic factor for renal involvement in FMF.
Keywords: Familial Mediterranean fever, Amyloidosis, Proteinuria, Renal involvement
First Name
 
Last Name
 
Email Address
 
Comments
 
Security code


Abstract View: 240

Your browser does not support the canvas element.


PDF Download: 30

Your browser does not support the canvas element.

Submitted: 17 Dec 2012
Accepted: 20 Jan 2013
ePublished: 30 Oct 2013
EndNote EndNote

(Enw Format - Win & Mac)

BibTeX BibTeX

(Bib Format - Win & Mac)

Bookends Bookends

(Ris Format - Mac only)

EasyBib EasyBib

(Ris Format - Win & Mac)

Medlars Medlars

(Txt Format - Win & Mac)

Mendeley Web Mendeley Web
Mendeley Mendeley

(Ris Format - Win & Mac)

Papers Papers

(Ris Format - Win & Mac)

ProCite ProCite

(Ris Format - Win & Mac)

Reference Manager Reference Manager

(Ris Format - Win only)

Refworks Refworks

(Refworks Format - Win & Mac)

Zotero Zotero

(Ris Format - Firefox Plugin)