Hadi Andishmand
1, Rastgar Olfati Karaji
2*, Afshin Darosaz Tabrizi
1, Shokoofeh Farshadyan
2, Hashem Andishmand
31 Department of Clinical Science, School of Veterinary Medicine, University of Azad Islamic of Tabriz, Tabriz, Iran
2 Department of Animal Science, School of Agriculture, University of Tabriz, Tabriz, Iran
3 Department of Nutrition Sciences and Food Technology, Shahid Beheshti University of Medical Sciences and Health Services, Tehran, Iran
Abstract
Backgrounds and Objectives: Testosterone Enanthate Analog (Testosterone Enanthate: TE) is used by athletes to increase muscle size and strength and also in patients with low plasma testosterone levels. Studies show that high levels of testosterone may affect the plasma lipid profiles. The purpose of this study was to evaluate the effect of supraphysiological dose of TE injection on plasma levels of total cholesterol, triglycerides, very low density lipoprotein (VLDL), low density lipoprotein (LDL) and high density lipoprotein (HDL) of adult male rats. Materials and Methods: In this study, 35 Wistar rats were randomly divided into 5 groups, each group consisted of seven rats: In Group I- Gonadectomized rat group received 5 mg/100 g body weight of TE; Group II- Not gonadectomized rat received 5 mg/100 g body weight of TE; Group III- gonadectomized rat received 0.5 ml olive oil; Group IV - Not gonadectomized rat received 0.5 ml olive oil; and Group V- Control group (intact rats not receiving any supplement). 60 days after receiving supplements, plasma levels of cholesterol, triglyceride, HDL and LDL were measured. Results: No significant difference in plasma cholesterol concentrations was found between different groups. Plasma triglyceride levels were significantly different in groups I (P< 0.001) and II (P< 0.05) and plasma VLDL levels in group I (P< 0.001) and II (P< 0.01) compare to it’s control group. No significant differences were found between groups I and II in the plasma LDL lipoprotein levels compare to the control group, but HDL levels decreased in group II compared to the control group (P< 0.05). Conclusion: TE consumption increased plasma levels of triglycerides and VLDL and decreased HDL levels; hence, the risk of cardiovascular disorders is higher in the people who receiving TE compare to others.