Abstract
Background and Objectives: “Bipolar I” disorder is a common and recurrent disorder that could be chronic and cause impairment in social and occupational functioning of patients. Many studies have been performed to find the best therapeutic methods for this disorder. Some findings indicate that combination of a mood stabilizer plus an atypical antipsychotic (such as Risperidone) is a useful and well-tolerated therapeutic regimen and its adverse effects is less than “typical” antipsychotics (e.g.Haliperidol). This study compares Lithium carbonate and combination of Lithium plus Risperidone or Haloperidol in treatment of Acute Mania.
Materials and Methods: This research is a double blind study that compares the efficacy of Lithium and combination of Lithium plus Risperidone or Haloperidol in 150 patients with acute mania that were hospitalized in Razi Psychiatry hospital of Tabriz.These patients were randomly divided into three groups including 50 persons in each one and were evaluated according to YRMS, GAF and DSM-IV-TR scales in 14 days-before the initiation and at the end of second week- of treatment.
Results: The results indicate different therapeutic response in these groups especially in the group that receive combination of Lithium plus Risperidone. According to YRMS, GAF and DSM-IV-TR scales, these differences were statistically significant.
Conclusion: In comparison of treatment with Lithium or combination of Lithium plus Haloperidol, combination of Lithium plus risperidone accelerates treatment, increases compliance and safety of treatment and reduces adverse effects.