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Med J Tabriz Uni Med Sciences Health Services. 2009;31(2): 15-20.
  Abstract View: 666
  PDF Download: 142

Biochemistry

Research

The Ketogenic Diet for Refractory Childhood Epilepsy

Mohammad Barzegar*, Alireza Ostad Rahimi, Skoofeh Eslampour, Shahla Shahbazi
*Corresponding Author: Email: mm_barzegar@yahoo.com

Abstract

Background and Objectives: The Ketogenic diet (KD) is a high fat, low protein and low carbohydrate, which controls refractory epilepsy. This prospective study sought to determine the ketogenic diet's effectiveness in children with refractory (to medication) epilepsy. Materials & Methods: Forty three children, ages 2 to 14 years were treated with the classical KD from 2002 to 2006. Response to treatment (reduction of seizure frequency > 50 %) tolerability and adverse events were analyzed. Results: Forty three children (mean age 5.8 years old), averaged 30 seizures per month before KD, despite on exposure to a mean 6.6 antiepileptic medications were treated with KD. At one month 93%, at 3 months 74%, at 6 months 51% and at 12 months 40% of patients remained on diet, 35% maintained the KD >12 months. At one month 77%, at 3 months 65%, at 6 months 44% and at 12 months 35% of patients showed a reduction of seizure frequency of >50%. Age, sex, seizure type and etiology did not predict response. Exposure more antiepileptic drugs before KD was with poor response at 12 months (P=0.007). High frequency of seizures before diet showed better response at 12 months (P=0.041). Most complications were mild and transient, but in 6 patients (14%) leads to discontinue the KD. Conclusion: The KD is an effective and safe treatment for children with refractory epilepsy.
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Submitted: 31 Oct 2009
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