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Med J Tabriz Uni Med Sciences Health Services. 2021;42(6): 745-755.
doi: 10.34172/mj.2021.016

Scopus ID: 85131152776
  Abstract View: 876
  PDF Download: 304

Original Article

The effect of 8 weeks high- intensity interval training and combined training on miR-16 expression in peripheral mononuclear blood cells of overweight/obese middle-aged women

Zhaleh Pashaei 1 ORCID logo, Afshar Jafari 2,3* ORCID logo, Mohammad reza Alivand 4 ORCID logo

1 Ph.D. Student, Department of Exercise Physiology, Faculty of Physical Education and Sport Sciences, Tabriz University, Tabriz, Iran
2 Department of Exercise Physiology, Faculty of Physical Education and Sport Sciences, Tabriz University, Tabriz, Iran
3 Department of Biological Sciences in Sport, Faculty of Sport Sciences and Health, Shahid Beheshti University, Tehran, Iran
4 Department of Medical Genetics, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
*Corresponding Author: *Corresponding author; E-mail: , Email: afshar.jafari@gmail.com

Abstract

Background: MicroRNAs are short non-coding RNA molecules that regulate different biological processes through regulating the expression of different genes and the miR-16 is one of the miRNAs that play an important role in obesity-related disorders. Therefore, the present study was conducted to determine the effect of high- intensity interval training (HIIT) alone and combined with resistance training (CHRT) on miR-16 expression in PBMCs of overweight/ obese middle-aged women.

Methods: Twenty-four overweight/obese, inactive, health middle-aged women participated in two homogeneous groups HIIT (5 bouts of running at 80%–85% of VO2max with active breaks at 60% of VO2max, 5 days/week, n=12) and CHRT protocols (3 day/week HIIT with 2 day/week resistance training protocol with 75-80% of 1-RM, n=12) for eight- week. MiR-16 expressions in PBMCs of overweight/obese middle-aged women were measured by real time- PCR before and 48h after the training protocols.

Results: Expression of miR-16 increased significantly in the both training protocols (HIIT: 2.32 fold, p=0.001 and CHRT: 4.96, p=0.006). However, there was no significant difference found between training protocols.

Conclusion: The eight weeks of HIIT and CHRT training are lead to equally changes in the expression of miR-16, as an anti-inflammatory epigenetic factor, in PBMCs of overweight/obese women.


How to cite this article: Pashaei Zh, Jafari A, Alivand MR. [The effect of 8 weeks High- intensity interval training and combined training on miR-16 expression in peripheral mononuclear blood cells of overweight/obese middle-aged women]. Med J Tabriz Uni Med Sciences Health Services. 2020;42(6):745-755. Persian.
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Submitted: 25 Apr 2019
ePublished: 24 Feb 2021
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