Medical Journal of Tabriz University of Medical Sciences and Health Services

Medical Journal of Tabriz University of Medical Sciences and Health Services. 2020;42(3): 263-272.
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Original Article

The effect of aerobic exercise training on hypoxia condition through PGC-1α angiogenesis signaling pathway in heart tissue of male westar rats

Soheila Rahimifardin 1 ORCID logo, Marefat Seiahkoheian 1* ORCID logo, Puran karimi 2 ORCID logo, Lotfali Bolboli 1 ORCID logo, Hassan Farhadi 3 ORCID logo

1 Department of Physical Education and Sport Sciences, Faculty of Education and Psychology, Mohaghegh Ardabil University, Ardabil, Iran
2 Neurosciences Research Center (NSRC), Tabriz University of Medical Sciences, Tabriz, Iran
3 Department of Physical Education and Sport Sciences, Ahar Branch, Islamic Azad University, Ahar, Iran
*Corresponding author; E-mail: Soheila_fardin@yahoo.com

Abstract

Background: Despite the effect of PGC-1α on biogenesis of mitochondria, the mechanism of its effect on cardiac angiogenesis has not yet been studied. Therefore, the purpose of this study was to investigate the effect of aerobic training and intermittent hypoxia on the expression of PGC-1α angiogenesis-related proteins in the cardiac tissue.

Methods: In an experimental study, Forty male Wistar rats weighing 220±20 gr were randomly divided into four groups; control (C), hypoxia (H), training (T), and Hypoxia + training (H+T) groups. Hypoxia group exposed to chronic intermittent hypoxia (PiO2≈106 mmHg, simulated altitude ≈ 3400 m, 14% oxygen for 8 weeks). And exercise group ran on a treadmill for 8 weeks, 5 session/ week. Then, relative protein density of PGC-1α, p-AMPK, ERRα, and VEGFA were measured with Western blot method.

Results: The aerobic training, intermittent hypoxia, aerobic training + hypoxia significantly increased relative protein density of PGC-1α, ERRα, and VEGFA compared to control group. Moreover, phosphorylation levels of AMPK showed an increase in all three groups compared to the control group.

Conclusion: Although hypoxia was an effective stimulator to induce the expression of PGC-1α and VEGFA and aerobic exercise was a potent phosphorylation inducer of AMPK, their combination did not have a synergistic effect.

Keywords: Hypoxia, Angiogenesis, Aerobic training, PGC-1α
How to cite this article: Rahimifardin S, Siahkohian M, Karimi P, Bolboli L, Farhadi H. [The effect of aerobic exercise training on hypoxia condition through PGC-1α angiogenesis signaling pathway in heart tissue of male Westar rats]. Med J Tabriz Uni Med Sciences Health Services. 2020 August-September; 42(3):263-272. Persian.
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Submitted: 01 May 2018
ePublished: 18 Jul 2020
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