Zahra Boorboor
1, Maryam Alem aref
1, Minoo Sadri
2, Javad Rasoli vani
3,4, Mahshid Aryafar
4, Saedeh Arab
2, Gholamreza Herfehdoost
1*1 Neurosince research center, Baqiyatallah University of Medical Sciences, Tehran, Iran
2 Department of biotechnology, Life Sciences Research Center, Malek Ashtar University of Technology, Tehran, Iran
3 Pharmaceutical Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran
4 Department of Nanotechnology, Pharmacy unit of Azad University, Tehran, Iran
Abstract
Background: Nano-fiber is a high-performance anti-microbial biocompatible polymer. And was used for Coverage of superficial wounds, such as burn wounds. These nanofibers can be a suitable alternative to conventional bandage.in this research the preparation of nanofibers and anti-bacterial properties has been studied.
Methods: Polymer solution of chitosan/ polyethylene oxide/ henna extract were prepared and using electros pining machine for nanofibers prepared and Its antibacterial properties was evaluated with Hinton agar medium containing the bacteria Escherichia coli and staphylococcus.
Results: The diameter of nanofibers were of 130 to 300 nm with SEM microscopy.the result of antibiogram tests with disks containing antibiotics and nanofibers indicates the zone of no growth bacterial growth on medium. As regards the prevent infection were the most important point in the treatment of burns and wounds so bandage containing nanofibers with anti- bacterial properties can be used instead of using antibiotics with numerous side effects .
Conclusions: The results of Antibiogram test indicate the high antibacterial properties of prepared Nano-fibers this is due to the antibacterial properties of chitosan and extracts Henna.