The Comparative Study of the Topical Tacrolimus Versus Topical Calcipotriol in Ptients with Hand and Facial Vitiligo

Abstract

Background & Objectives: Vitiligo is an acquired disease due to progressive lack of performance of melanocytes and appears as ring depigmentated patches and macules. About %2 of people are involved and because of unpleasant appearance, it creates emotional stress on patients .So new and better treatments are needed. This study was conducted to compare effectiveness of topical tacrolimus with topical calcipotriol in pigmentation of vitiligo patients. Materials & Methods:This study was done in double-blind randomized clinical trial on patients facial and hand vitiligo with under %20 involvement of body surface. Patients were categorized in two groups with tacrolimus and calcipotriol treatments and were evaluated and followed up for 12 months. Results: In statistical analysis, there was no significant difference between the effects of both drugs on progression of pigmentation, but their on facial vitiligo was better than hand vitiligo(p=0.04).Side effects of treatment in both groups were mild and no serious side effects were reported, but Tacrolimus had significantly minimal side effects rather than Calcipotriol (p=0.02). Conclusions:In this study,efficacy of topical tacrolimus was better than topical calcipotriol on face and efficacy of calcipotriol was better than tacrolimus on hand vitiligo.