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Med J Tabriz Uni Med Sciences. 2024;46(1): 38-47.
doi: 10.34172/mj.2024.012
  Abstract View: 121
  PDF Download: 30

Endocrine System

Original Article

Anti-inflammatory effect of swimming exercise and genistein in combination in the pancreas of ovariectomized diabetic rats

Balal Khalilzadeh 1 ORCID logo, Mohammad Zayer 2 ORCID logo, Hadi Yousefi 2,3* ORCID logo

1 Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
2 Student Research Committee, Khoy University of Medical Sciences, Khoy, Iran
3 Department of Basic Medical Sciences, Khoy University of Medical Sciences, Khoy, Iran
*Corresponding Author: Email: yousefi_h@khoyums.ac.ir

Abstract

Background. Menopause is associated with an increase in blood sugar and an increase in inflammatory cytokines. Exercise and genistein have biological activities, including anti-inflammatory and antidiabetic activity. This study examined the combined effects of regular swimming exercise and genistein as a preventive strategy against inflammation and pancreatic cell damage in ovariectomized diabetic rats.

Methods. A total of 42 female Wistar rats were divided into six groups: Sham, ovariectomy (OVX), diabetic ovariectomy (OVX.D), diabetic ovariectomy + exercise (OVX.D.E), diabetic ovariectomy + genistein (OVX.D.G), and diabetic ovariectomy + exercise + genistein (OVX.D.E.G). Animals underwent swimming training or received genistein or a combination of both for eight weeks. At the end of this period, the levels of TNF-α, Nf-κB, IL-1β, and SIRT1 proteins were evaluated using western blot in pancreatic tissue.

Results. Ovariectomy increased the expression of TNF-α, Nf-κB, and IL-1β and decreased the expression of SIRT1, and these effects were more significant in ovariectomized diabetic rats. Treatment with genistein and swimming exercise individually reversed these changes in the level of proteins and improved the inflammation, but the combined effect of these two interventions exhibited more effect.

Conclusion. The combination of genistein and regular swimming exercise provides enhanced protection for pancreatic tissue and effectively prevents damage to it. Therefore, performing appropriate physical activities and consuming compounds containing phytoestrogens can prevent the occurrence of disorders such as diabetes during menopause.

Practical Implications. The results of this study can guide health policymakers to prevent disorders and complications caused by menopause.


How to cite this article: Khalilzadeh B, Zayer M, Yousefi H. Anti-inflammatory effect of swimming exercise and genistein in combination in the pancreas of ovariectomized diabetic rats. Med J Tabriz Uni Med Sciences. 2024;46(1):38-47. doi: 10.34172/mj.2024.012. Persian.
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Submitted: 07 Nov 2023
Accepted: 30 Dec 2023
ePublished: 04 Feb 2024
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