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Med J Tabriz Uni Med Sciences. 2024;46(2): 199-209.
doi: 10.34172/mj.2024.026
  Abstract View: 137
  PDF Download: 48

Radiology

Original Article

Investigating TE effects on the relationship between signal intensity and PVP-grafted SPION concentration in T2-weighted Spin Echo imaging

Mahmood Nazarpoor 1,2* ORCID logo, Hassan Fattahi 3

1 Department of Biochemistry and Biophysics, Faculty of Advanced Sciences and Technology, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran
2 Department of Radiology, Faculty of Paramedicine, Tabriz University of Medical Sciences, Tabriz, Iran
3 Department of Polymer Engineering, Composite Research Institute, Faculty of Materials and Manufacturing Technologies, Malek Ashtar University of Technology, Tehran, Iran
*Corresponding Author: Email: mnazarpoor@yahoo.co.uk

Abstract

Background. Because ionizing radiation and radioactive materials are not used in MRI images and their good spatial resolution, it has been widely used in the diagnosis of diseases. But for a more accurate diagnosis of some diseases, it is necessary to inject contrast material. Contrast materials are metal ions of paramagnetic elements such as gadolinium (Gd) or superparamagnetic iron oxide nanoparticles (SPIONs). This study aims to investigate the effect of echo time (TE) on the signal intensity of PVP-grafted iron oxide nanoparticles on spin echo T2-weighted images as a negative contrast material (T2-contrast).

Methods. Prepared nanoparticles (SPIONs grafted with PVP) in different concentrations (0-0.600 μmol Fe/L) that were poured inside the test tubes were spin echo T2-weighted imaged by an MRI scanner (1.5 T).

Results. The curves of nanoparticle concentration versus the signal intensity show that with increasing nanoparticle concentration, the signal intensity decreases. Also, at a constant TE, the higher nanoparticle concentration has lower signal intensity.

Conclusion. The produced nanoparticle (PVP-grafted iron oxide nanoparticles) can be used in clinical work as a negative contrast material due to the behaviour it showed in different concentrations and TE.

Practical Implications. Nanoparticles are used as a contrast agent in MRI imaging. The results of this study show that the prepared contrast agent can be used as a negative contrast agent in clinical imaging.


How to cite this article: Nazarpoor M, Fattahi H. Investigating TE effects on the relationship between signal intensity and PVP-grafted SPION concentration in T2-weighted Spin Echo imaging. Med J Tabriz Uni Med Sciences. 2024;46(2):199-209. doi: 10.34172/mj.2024.026. Persian.
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Submitted: 05 Apr 2023
Accepted: 19 Jun 2023
ePublished: 13 Apr 2024
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