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Med J Tabriz Uni Med Sciences. 2023;44(6): 455-465.
doi: 10.34172/mj.2023.001

Scopus ID: 85150993573
  Abstract View: 656
  PDF Download: 165

Infectious Diseases

Meta-analysis

Prevalence of Hepatitis B genotypes worldwide and in Iran: A meta-analysis

Kosar Baghernezhad 1 ORCID logo, Mohammadhossein Somi 2 ORCID logo, Dara Rahmanpour 2 ORCID logo, Morteza Ghojazadeh 3 ORCID logo, Leila Rsotamizadeh 3 ORCID logo, Masood Shirmohammadi 2 ORCID logo, Hanieh Salehi-Pourmehr 3 ORCID logo, Amirreza Naseri 1* ORCID logo

1 Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran
2 Research Cener for Liver and Gastrointestinal Diseases, Tabriz University of medical sciences, Tabriz, Iran
3 Research Center for Evidence-Based Medicine, Iranian EBM Centre: A Joanna Briggs Institute (JBI) Center of Excellence, Tabriz University of Medical Sciences, Tabriz, Iran
*Corresponding Author: Email: naseria@tbzmed.ac.ir

Abstract

Background. Chronic hepatitis B is associated with different long-term outcomes in various regions. One of the critical predictors of clinical outcomes is the genotype of Hepatitis B virus (HBV). The current study investigated the frequency of worldwide and Iranian national HBV genotypes.

Methods. Electronic search was performed through Medline (via Ovid), Embase, Web of Science, and Persian databases. Furthermore, the references of eligible articles were manually checked. The quantitative synthesis was conducted using the 2nd version of comprehensive Meta-analysis software (CMA.2).

Results. In total, 5817 records were retrieved, and after removing duplicate studies, 3701 were screened at the title/abstract level. A total of 350 eligible studies were identified in the end.D genotype had the highest frequency (43.50%; 95% CI: 39.60 to 47.50), and the H genotype had the lowest frequency (1.2%; 95% CI: 0.6 to 2.7) globally. In 29 studies conducted in Iran (97.0%), genotype D was identified. Genotype E was the most prevalent in the African Region, followed by A in the American Region, B and C in the South-East Asian Region, D in the European Region, and C in the Western Pacific Region.

Conclusion. The most prevalent genotype of HCV worldwide and in Iran is D. Furthermore, HBV genotype frequencies vary according to WHO regions. A prediction of progression could be made based on these results.

Practical Implications. 1.According to the results of the meta-analyses, the D genotype had the highest frequency (43.50%; 95% CI: 39.60 to 47.50) and the genotype H had the lowest frequency (1.2%; 95% CI: 0.6 to 2.7) globally. 2.In 29 studies conducted in Iran (97.0%), genotype D was identified. 3. Genotype E was the most prevalent in the African Region, followed by A in the American Region, B and C in the South-East Asian Region, D in the European Region, and C in the Western Pacific Region.


Keywords: Hepatitis B, Genotype, Iran

How to cite this article: Baghernezhad K, Somi M H, Rahmanpour D, Ghojazadeh M, Rsotamizadeh L, Shirmohammadi M, Salehi-pourmehr H, Naseri A R. Prevalence of Hepatitis B genotypes worldwide and in Iran: A meta-analysis. Med J Tabriz Uni Med Sciences. 2023; 44(6): 455-465. doi: 10.34172/mj.2023.001. Persian.
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Abstract View: 657

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PDF Download: 165

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Submitted: 21 May 2022
Revision: 29 Oct 2022
Accepted: 30 Oct 2022
ePublished: 01 Jan 2023
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