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Med J Tabriz Uni Med Sciences Health Services. 2021;42: 684-691.
doi: 10.34172/mj.2021.009
  Abstract View: 183
  PDF Download: 122

Original Article

Serum C-reactive protein and erythrocyte sedimentation rate changes in children after adenotonsillectomy

Mehrnoosh Mousavi Aghdas 1 ORCID logo, Nikzad Shahidi 1* ORCID logo, Shahin Abdollahi Fakhim 1 ORCID logo

1 Department of Otolaryngology Head and Neck Surgery, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
1 Department of Otolaryngology Head and Neck Surgery, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
*Corresponding Author: Email: nikzadsh@yahoo.com

Abstract

Background: Sleep-disordered breathing is a common problem in children and is associated with increased cardiovascular morbidity. The circulating level of C-reactive protein, a pro-inflammatory protein, is associated with increased risk for atherosclerosis. The aim of this study was the comparison of C-reactive protein level and erythrocyte sedimentation rate in children with tonsillar hypertrophy before and after adenotonsillectomy.

Methods: All patients aged between 4 to 10 years who had underwent adenotonsillectomy due to obstructive sleep apnea were enrolled. Serum C-reactive protein and erythrocyte sedimentation rate were measured before and after adenotonsillectomy. Data were analyzed with SPSS version 19.

Results: In this study, 384 patients were enrolled. The average age of the patients was 6.7 years. The C-reactive protein level in 91 patients (23.7 %) was decreased and in 286 patients (74.5%) did not change and in 7 patients (1.8%) it was increased. Decreasing serum C-reactive protein level and erythrocyte sedimentation rate was statistically significant after adenotonsillectomy (P-value < 0.05).

Conclusion: Obstructive sleep apnea induces a systemic inflammatory response so frequently associated with an increase in serum C-reactive protein and erythrocyte sedimentation rate that is reversible with surgery and if left untreated may lead to cardiovascular morbidity.

Keywords: CRP, ESR, Adenotonsillectomy

How to cite this article: Mousavi Aghdas M, Shahidi N, Abdollahi Fakhim Sh. [Serum C-reactive protein and erythrocyte sedimentation rate changes in children after adenotonsillectomy]. Med J Tabriz Uni Med Sciences Health Services. 2021;42(6): 684-691. Persian.
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Submitted: 26 Feb 2019
Revision: 03 Sep 2020
Accepted: 07 Sep 2020
ePublished: 24 Feb 2021
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