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Med J Tabriz Uni Med Sciences. 2021;43: 444-455.
doi: 10.34172/mj.2021.070
  Abstract View: 110
  PDF Download: 57

Original Article

The effect of continuous aerobic exercise on serum angiogenic and angiostatic factors in induction model of acute myocardial infarction male rats with coronary artery disease

Elham Dehghan 1* ORCID logo, Aliasghar Ravasi 2 ORCID logo, Reza Nouri 3 ORCID logo, Abbasali Gaeini 2 ORCID logo, Maryam Nekooei 4 ORCID logo, Mohammadamin Delavari 5 ORCID logo, Masoud Khorsandi Kolur 5 ORCID logo

1 Department of Sport Sciences, Bushehr Branch, Islamic Azad University, Bushehr, Iran
2 Department of Exercise Physiology, Faculty of Sport Sceince, University of Tehran, Tehran, Iran
3 Department of Sport Sciences, Kish International Campus, University of Tehran, Kish, Iran
4 Department of Biochemistry, Bushehr University of Medical Sciences, Bushehr, Iran
5 Department of Sport Sciences, Faculty of Human Sciences, University of Hormozgan, BandarAbbas, Iran
*Corresponding Author: Email: elhamdehghan24@yahoo.com

Abstract

Background. Aerobic training somewhat corrects endothelial dysfunction in patients with coronary artery disease (CAD), but the most effective form of exercise is still unclear; therefore, the purpose of the present study was to investigate the effect of 8 weeks of continuous aerobic exercise on serum vascular endothelial growth factor (VEGF) as an angiogenic factor and endostatin (ES) as an angiostatic factor in male rats with coronary artery disease.

Methods. The subjects of the present experimental study were 30 healthy male 2-months old Wistar rats divided into three groups: the experimental group, the control group with coronary artery disease, and the healthy control group. After rupturing 20 of the rats by isoproterenol, 10 rats in the experimental group performed eight weeks of continuous aerobic exercise on a treadmill, with an incremental intensity of 50% in the first session to 78% in the last session, whereas both control groups did not exercise. Seventy-two hours after the final training session, blood samples were taken for serum VEGF and ES indices, and one-way ANOVA with Scheffer posthoc tests was used to compare the mean of variables among the studied groups.

Results. The results showed that discontinuous aerobic exercise could increase the blood VEGF in rats with coronary artery disease (P≤0.01), while there was no difference in the level of endostatin in the experimental group compared with control groups (P>0.05).

Conclusion. It seems that continuous aerobic exercises can be used in the rehabilitation of patients with coronary artery disease and might be effective in the process of angiogenesis.

Keywords: Coronary artery disease, Aerobic exercise, Endostatin, vascular endothelial growth factor

How to cite this article: Dehghan E, Ravasi AA , Nouri R, Gaeini AA, Nekooei M , Delavari MM , Khorsandi kolur M, The effect of continuous aerobic exercise on serum angiogenic and angiostatic factors in induction model of acute myocardial infarction male rats with coronary artery disease. Med J Tabriz Uni Med Sciences. 2021;43(5):. Persian.
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Submitted: 02 Jun 2020
Revision: 09 Aug 2020
Accepted: 05 Sep 2020
ePublished: 01 Nov 2021
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