Comparison between Hemodynamic Effects of Propofol-remifentanil and Isoflurane for Induction of Anesthesia in Lumbar Disc Operations

Abstract

Background and Objectives: There are different anesthetic methods for hemodynamic stabilization during lumbar disc surgery. Anesthesias with intravenous drug including propofol-remifentanil and isoflurane have acceptable results inthis regard. In this study we compared the hemodynamic effects of these two anesthesia methods in patients, candidate for lumbar disc surgery. Materials and Methods: In this study, 70 patients, who were candidate for lumbar disc surgery underwent general anesthesia using propofol-remifentanil or isoflurane. After induction with lidocaine, propofol and sisatracorium, anesthesia was maintained in isoflurane group with controlled respiration using oxygen and N2O with 50% ratio with isoflurane 1% and in propofol-remifentanil group, with controlled respiration using 100% oxygen with propofol 5 mg/kg/h and remifentanil 0.125 µg/kg/min. Hemodynamic findings during surgery and after surgery were recorded in both groups. Results: There were no significant differences between groups in their systolic and diastolic blood pressure, heart rate and oxygen saturation. Also, both groups were similar in their return to spontaneous breathing and extubation, time for eye opening and ability of verbal communication, meanwhile, frequency of general presentations such as chill, agitation, degree of post-surgery hypoxia. Nausea and vomiting were not significantly different between two groups. Conclusion: Anesthesia with both methods; intravenous propofol-remifentanil or inhaled isoflurane in patients who are undergoing lumber disc surgery regarding to heir hemodynamic effects such as hypotension and brady cardia are acceptable.

Keywords: Lumbar Disc Surgery, Hemodynamic Changes, Propofol-Remifentanil, Isoflurane