Formulation and Evaluation of an Herbal Cream from Dry Extract of Glycyrrhiza Globra and Fumaria Parviflora

Abstract

Background and Objectives: Fumaria parviflora is a species of flowering plant native to Europe, Asia, and Africa, but it is common and widely distributed in many other parts of the world. F.parviflora is a weak tonic, slightly diaphoretic, diuretic, aperients and valuable in all visceral obstructions, particularly those of the liver, Liquorice is the root of Glycyrrhiza glabra from which a sweet flavor can be extracted. The liquorice plant is native to southern Europe and parts of Asia. Modern research has shown it to have effects uponliver, the endocrine system and other organs. It is tonic, diuretic, demulcent, expectorant, emenagogueand Laxative. Material and Methods: The plants were extracted using maceration method. The extract were incorporated in absorption base and in the best formulation physicochemical tests such as content uniformity, creaming and coalescence, pH changing and microbial Challenge test were determined. Results: After concentration of extract and freeze-dried them, weight from every 100gram extract of Glycyrrhiza were 16.6g and for Fumaria were 13.8gr. The pH of formulation after 3 month was in the range of 5.7-6.7. The prepared formulation appropriate physicochemical characteristics with respect to appearance, consistency, viscosity, content uniformity and stability parameters. Conclusion: The prepared formulation was stable in the experimental condition and this formulation can be selected for the clinical trial on skin disorders.

Keywords: Fumaria Parviflora, Glycyrrhiza Glabra, Cream