Azim Rezamand
1, Saeid Aslanabadi
1, Mohammadamin Rezazadehsaatlou
2*, Laleh Alizadeh
11 Pediatric Health Research Center, Children Hospital, Tabriz University of Medical Sciences, Tabriz, Iran
2 Tuberculosis and Lung Disease Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
Abstract
Background and Objectives: Wilm’s tumor is the second most prevalent intra-abdominal and fifth malignant in pediatric medicine. This tumor includes at least 6 percent of all cancers in children and 95% of all renal tumors in pediatrics. Regarding to its high prevalence and the importance of determining its outcome and therapeutic process for designing a better road map for these patients and also because of the lack of related studies in our region we decided to do this study in order to evaluate the clinical features and outcome of patients with Wilm’s tumor referring to Tabriz Children hospital from 2003 to 2009. Materials and Methods: In this descriptive study, All 44 patients younger than 14 years old which have been operated and received chemotherapy from 2003 to 2009 were enrolled in this study. Data such as age, gender, bleeding, weight loss, hemoglobin, platelet, WBC, PT and PTT counts and associated anomalies were gathered from the hospital records. Results: Eight patients (18.2%) had received chemotherapy before the operation in our study. 50% of tumors was located in right side, 45.5% were located in left side and 4.5% were bilateral. Most of the patients (20 patients, 45.5%) were in stage III of the disease. Tumor histopathology was favorable in 36 (81.8%) and unfavorable in 8 (18.2%). Associated anomalies were seen in 3 (6.8%) patients. Most seen sign were mass feeling, weight loss, loss of appetite, malaise and fever in this study. Most complications were seen in liver and lungs. No statistically significant difference was seen between two genders regarding the outcome (p=0.48), complication (p=0.96) and disease stage (p=0.43). The outcome was statistically significant different between two kinds of histopathology (p=0.007). Conclusions: The age average was lower in our study comparing with similar studies. The histopathology of tumor was favorable in most of our patients and the majority was in stage III of the disease. As it was expected there was a significant relation between histopathology and the outcome of the patients.