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Med J Tabriz Uni Med Sciences Health Services. 2014;36(4): 50-55.
  Abstract View: 697
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Original Article

Immunophenotypically Subtypes of Acute Lymphoblastic Leukemia Among the patients referred to the Tabriz Children Hospital (2003-2006)

Azim Rezamand 1, Mohammadamin Rezazadehsaatlou 2*, Kazem Ghafarzadeh Sakha 1, Neda Daeioghli Leilabadi 2

1 Children's Health Research Center, Children's Hospital, Tabriz University of Medical Sciences, Tabriz, Iran
2 Chronic Kidney Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
*Corresponding Author: Email: dr_amin_re@yahoo.com

Abstract

Background and Objectives: Acute leukemia is the most common childhood malignancy, which accounts for approximately one-third of all pediatric cancers; meanwhile, Acute Lymphoblastic Leukemia (ALL) constituted about 75% of pediatric acute leukemias. Common constitutional symptoms include fever, faitugs, pallor bone pain and disruption of normal hematopoesis. Immonophenotyping by flow cytometry is performed to further characterization of ALL subtypes. This study was designed and performed in order to determine the Immunophenotypically Subtypes of Acute Lymphoblastic Leukemia in children in Azerbaijan region. Materials & Methods: This study was performed as a cross- sectional descriptive survey. The population under concern contained children suffering from ALL who were admitted to Tabriz Children Hospital during 2003- 2008. Data required for this survey was worked out by the researchers from patient’s files in the hospital. Results: All of 150 patients with ALL who had complete file data were enrolled in this study, 84 were males (56%) and 66 were females (44%). The patient’s mean age was years. The mean hemoglobin and platelet count were 8/76 ± 2/45 gr /dl and 116000 ± 10720 mm3, respectively. The most prevalent immonopeonotype was pre-Bcell and the least one was mixed type. Conclusion: Epidemologic distribution of blood parameters and some clinical signs also ALL immonophenotype in Easte Azerbaijan are compatible with other studies in other parts of the world.
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Submitted: 12 Feb 2014
Accepted: 17 Apr 2014
ePublished: 29 Oct 2014
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