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Med J Tabriz Uni Med Sciences Health Services. 2014;36(2): 30-35.
  Abstract View: 429
  PDF Download: 109

Original Article

Tumor Necrosis Factor Alpha Serum Level in Wet Type Age-Related Macular Degeneration

Alireza Javadzadeh 1, Amir Ghorbanihaghjo 1, Yashar Amizadeh 2*, Nader Baharivand 1

1 Nikookari Eye Hospital, Department of Ophthalmology, School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
2 School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
*Corresponding Author: Email: yashar.amizadeh@gmail.com

Abstract

Background and Objectives: Wet type Age-related Macular Degeneration (Wet type AMD) is a debilitating ocular disease which generally occurs among elderly population. Tumor Necrosis Factor alpha (TNF-α) is a reactive phase protein which is associated with Alzheimer, atherosclerosis, type 2 diabetes mellitus and aging. Materials and Methods: In this case-control study, 40 eyes of 40 patients with wet type age-related macular degeneration and 49 normal eyes of 49 healthy people were randomly selected and serum levels of TNF-α, lipid profile and fasting blood glucose were checked. Results: The difference of mean ages and male to female ratio were not statistically significant (P=0.441, P=0.091). Serum level of TNF-α was significantly higher among patients with retinal degeneration (Median (IQR) = 0.2 (0.1-0.58) vs. 0.1 (0-0.2); P=0.002). Conclusion: TNF-α would have a role in the pathogenesis of the wet type age-related macular degeneration and pharmaceutical and/or non-pharmaceutical interventions might decelerate or even cease the progression of this ominous disease.
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Submitted: 18 May 2013
Accepted: 06 Jul 2013
ePublished: 25 Jun 2014
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