Med J Tabriz Uni Med Sciences Health Services. 2014;36(1): 20-27.
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Original Article

Effect of Aerobic Training with Omega-3 Consumption on Soluble Adhesion Molecules in the Obese Women

Asghar Tofighi, Ghafour Ghafari*

1 Department of Exercise Physiology, School of Medicine, Uremia University of Medical Sciences, Urmia, Iran


Background and Objectives: Obesity is a growing cause of cardiovascular diseases. Accordingly, the aim in present study was to investigate the effect of Aerobic Training with Omega-3 Consumption on Soluble Adhesion Molecules in the Obese Women. Materials and Methods: In a double-blind study, 40 obese women (BMI ≥30) 55 to 65 years were selected, and randomly divided into 4 groups (n=10 for each group): exercise-supplementation, exercise-placebo, supplementation, and control. Subjects in the supplementation group consumed 2080 mg omega-3 daily and the placebo group consumed a 0.02 dextrose solution as a placebo. The exercise program comprised aerobic exercise to 45% to 65% maximum heart rate for 8 weeks; each session was sustained for 40 min and continued for 3 sessions per week. Results: Exercise, supplementation and combined exercise – supplement can sICAM-1 concentration significantly decreased (P< 0.05). On the other hand, serum sVCAM-1 concentration decreased significantly only in the exercise-supplement group (combined) and IL-6 concentration significantly decreased in the exercise group and exercise-supplement group (combined) (P < 0.05). Conclusions: Measurement of Adhesion Molecules is a useful method in the diagnosis of inflammation and vascular disorders. In addition, regular aerobic exercise and omega-3 supplements are two effective and moderating factors; in reducing the of adhesion molecules and pre-inflammatory cytokines.
Keywords: sICAM-1, sVCAM-1, IL-6, ω3 fatty acid, obese Women, aerobic training
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Submitted: 04 Apr 2013
Accepted: 06 May 2013
ePublished: 30 Apr 2013
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