Parviz Torkzaban
1, Reza Pourabbas
2, Mehrdad Hajilooi
3, Farnaz Jafari
4, Ali Zarandi
5*1 Research center of dentistry, School of Dentistry, Hamedan University of Medical Sciences, Hamedan, Iran
2 Department of Periodontics, School of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran
3 Department of Immunology, School of Medicine, Hamedan University of Medical Sciences, Hamedan, Iran
4 Tabriz University of Medical Sciences, Tabriz, Iran
5 School of Dentistry, Hamedan University of Medical Sciences, Hamedan, Iran
Abstract
Backgrounds and Objectives: The main purpose of one-stage full-mouth disinfection is the rapid elimination or depletion of all oro-pharyngeal pathogens using scaling and root planning, subgingival periodontal pocket irrigation and tongue disinfection. The aim of the present study was to evaluate the effect of this technique on serum levels of IL-17 and IL-23 in patients with moderate-to-advanced chronic periodontitis. Materials and Methods: This randomized clinical trial study conducted on 24 eligible patients with moderate to advanced chronic generalized periodontitis. 20 (11 male- 9 female), healthy subjects and with no history of drug therapy during the last 6 months were included in the study. Blood samples were taken from the patients before the intervention. Then, full-mouth disinfection was carried out in one session. Blood samples were taken again 6 weeks after the intervention. The ELISA method was used to evaluate serum levels of IL-17 and IL-23. Results: The Pre and post-treatment serum levels of IL-17 were 103.8±38.6 and 14.1±8.6 pg/mL, respectively (P=0.003); in case of IL-23, The Pre and post-treatment serum levels were 124.9±40.1 and 17±8.8 pg/mL, respectively (P = 0.001). The differences were statistically significant in both cases. Conclusion: In patients with moderate-to-advanced chronic periodontitis, serum levels of IL-17 and IL-23 significantly decrease subsequent to one-stage full-mouth disinfection.