Effect of Impaired Renal Function on Serum Levels of Tumor Marker CA15-3, AFP, CA19-9 and CEA

Abstract

Background and Objectives: Since the reduced renal excretion of tumor markers in the follow-up and treatment of patients with renal insufficiency or hemodialysis is controversial. The aim of this study was to evaluate serum levels of different markers CA15-3, AFP, CA19-9 and CEA in patients with impaired renal function. Materials and Methods: 100 patients admitted to the district hospital laboratory of Imam Reza and Amiralmomenin in Tabriz from July 2011 to November 2012 were selected for the study. Five groups of healthy,dialysis and non-dialysis patients with renal failure that were divided into three other groups based on creatinine clearance Results: Relationship between different groups in serum markers CEA (P = 0.99) and CA19-9 (P = 0.29) was observed. In terms of serum markers AFP (P <0.001) and CA15-3 (P <0.001) correlation is observed. Correlation between creatinine clearance and the CEA (r = 0.05, P = 0.625), there was not significant, But the correlation between creatinine clearance and AFP - P <0.001 and r = 0.53 between creatinine clearance and CA19-9 (r = -0.171, P = 0.089) and between creatinine clearance and CA15-3 (p <0.001, r = -0.412) were significantly related. Conclusions: According to these results, it appears that the use of tumor markers in patients with impaired renal function should be performed with special precautions.

Keywords: Impaired renal function, Tumor markers, Hemodialysis