Treatment of Candidia Albicans Cutaneous Infection by Ethanol Extract of Propolis in an Experimental Model

Abstract

Backgrounds and Objectives: Propolis is a resinous substance collected by honeybees from buds and leaves of trees and plants; it then mixed with pollen and secreted enzymes by bees. This study was aimed to assessing the anti-fungal activity of Ethanol Extract of Propolis in an experimental of cutaneous candidial infection. Materials and Methods: In this study, twenty-four male rabbits were studied. Animals were randomly divided into six equal groups: positive control group, negative control group, and four treated groups. The four test groups were which given different doses of EEP (125, 250, 500 and 1000 μg/ml) the positive control group received the standard Nystatin treatment and negative control group received only Topical Normal saline, in each groups local treatment was performed, two times a day for 20 days. Results: The results showed that EEP in its highest dose of 1000µg/ml was effective after 3 days of treatment in comparison. Clinical signs of cutaneous candidiasis were healed in Nystatin group after 5 days. Conclusion: Ethanol Extract of Propolis in concentration 1000µg/ml is an effective treatment for Candida albicans cutaneous candidiasis. It could be a suitable alternate for renowned chemical drugs.

Keywords: Candidiasis, Cutaneous, Candida albicans, Propolis, Rabbit