Abstract
Background and Objectives: Mean platelet volume (MPV) is considered as a parameter in differential diagnosis of common platelet disorders which is related to platelet production. This study was done to evaluate MPV changes in common disorders of platelet such as leukemia,ITP and aplastic anemia.
Materials and Methods: One hundred patients admitted with platelet disorders at Tabriz Pediatric Medical Center were Compared with 20 patients without hematological problem. The factors studied included platelet, WBC,Hgb and MPV which were done by H1 Coulter. Sixty six cases studied had leukemia, 27 patient had ITP and 7 out of them had aplastic anemia. The final diagnosis was done by BMA.
Results:In patients having leukemia with average platelet count of 54154/mm³ and MPV of 7.29 ± 1.19 there was not meaningful relationship between disease and MPV (p>0.067). Patients with ITP had average platelet count of 22359/mm³ and MPV of 10.40 ± 1.280 which did not show a meaningful relationship between disease and MPV (p>0.05), but in patients with aplastic anemia average platelet count 25142/mm³ and MPV 4.48 ± 0.91 showed a meaningful relationship between aplastic anemia and MPV (p<0.001).
Conclusion: Although MPV is an indicator of platelet production and it decreases in bone marrow failure and increases in bone marrow production activity ,this study shows that MPV is only helpful in diagnosis of aplastic anemia and has no diagnostic value in leukemia or ITP.