Abstract
Background and Objectives: Serum levels of highly sensitive C-reactive protein (hs-CRP), Malondialdehyde (MDA) are indices of inflammatory and lipid oxidative and were evaluated in patients with coronary artery disease (CAD) and the results compared with these obtained from control. This study was performed on non-diabetic, non-smoking individuals.
Materials and Methods: One hundred twenty subjects including 60 patients with angiographically diagnosed CAD and 60 age and sex matched normal controls were studied. Lipids and lipoproteins parameters were measured by standard methods. The levels of hs-CRP were determined by immune-turbidometeric method. The concentrations of MDA were assayed calorimeterically using Thiobarbitoric reaction.
Results: Comparing with the controls, serum levels of hs-CRP and MDA were significantly higher in the patients with CAD (p<0.05 in the both cases). In the CAD group serum concentrations of Total Cholesterol, Triglyceride, LDL-C were markedly higher than those in the control group but that of HDL-C was lower than controls (p<0.05 in all cases).
Conclusion: In addition to diabetes and smoking other factors are involved in inflammation and oxidative stress in CAD patients. It was concluded that complementary antioxidant may be useful in prevention of atherosclerosis and CAD.