Evaluation of Gastric Changes in Dyspeptic First Degree Relatives of Patients with Gastric Adenocarcinoma in Comparison with Dyspeptic Patients with Negative Familial History

Abstract

Background and Objectives: In a community with high prevalence of gastric cancer, dyspepsia in the first degree relatives of patients with gastric cancer could be an alarming sign. In this study we evaluated the gastric mucosal changes in, dyspeptic, first-degree relatives of patients with gastric malignancy and compared it with a control group. Materials and Methods: In an analytic-descriptive setting, 200 dyspeptic patients were recruited, 99 and 101 patients in case and control groups, respectively. Upper endoscopy was done in all patients and biopsy was performed in 5 different gastric zones for further histopathological assessments. The results were compared between the two groups. Results: Ninety nine (M/F 50/49) patients in the case group and 101patients in the control group (M/F 48/5348) were enrolled, respectively. Endosmotically significant lesion was more frequent in the control group (38.9% case vs. 69.3% control x2test; P=0.001). Helicobacter pylori infection was determined in 76.8 and 69.1 percent of patients in the case and control groups, respectively (P=0.26).Chronic inflammation (median score 9.7 case vs. 8.5 control P =0.0001) and polymorph activity (median score 6.9 case vs.3.4 control p=0.03) were more sever in case group. Corpus predominant gastritis or pangastritis was more common in the Case group (77.8% case vs. 63.4% in the control, P = 0.0001). Precancerous lesion was more severe (Median scores 0.39 case v 0.15 control, T test, P =0.007) in case group. Conclusion: This study showed that gastric mucosal precancerous lesions are more prevalent in dyspeptic patients with positive history of gastric cancer.