Abstract
Background and Objectives: Relation between renin-angiotensin system gene polymorphism and renal allograft dysfunction is the matter of debate. We designed this study to evaluate this controversy in Iranian patients.
Materials and Methods: The present study was performed on 108 renal transplant recipients. Following of the DNA extraction, the genotypes of the angiotensin converting enzyme (I/D), angiotensinogen (M235T) and angiotensin II type 1 receptor (A1166C) were determined by PCR. The magnitude of clearance of creatinine in the setting of each of the above renin-angiotensin system polymorphisms was determined by MDRD formula. P ≤ 0.05 was considered to indicate statistical significance.
Results: There was no association between the each genotype of the renin-angiotensin system and clearance of creatinine, serum urea, cyclosporine through level and the degree of urinary protein excretion rate, But in addition of the genotypes, the patients with DD+CC genotype in comparison of the patients with II+AA genotype had lower clearance of creatinine and higher creatinine level, urinary protein excretion rate (P=0.05, P=0.002, and P=0.03, respectively). Likewise, other combinations hadn’t such association.
Conclusion: Although, none of the gene polymorphisms of the renin-angiotensin system had any impact on renal allograft function, but evaluation of combinations of these genotypes can predict the outcome of renal allograft function.