Abstract
Background and Objectives: Ureteral stones are important conditions which are observed primarily or secondarily after ESWL or PNL. They cause obstruction of urinary tract and Intervention for stone release also has some complication. The aim of this study was to evaluate the efficacy of the addition of Tamsulosin to traditional expulsive therapy for the treatment of distal-ureteral stones and release of obstruction.
Material and Methods: Between march 2005 until march 2006 a series of 36 patients randomly were included in one clinical trial study for the management of symptomatic distal-ureteral calculi .they randomly divided into group 1 (N=18) who received indomethacin and hydrochlorotyazid and group 2 (N=18) who received the same therapy plus Tamsulosin (0.4 mg/daily).There were no differences between the groups with respect to age, sex, or stone size. The primary endpoint was the expulsion rate. Need for analgesics and hospitalization, were the secondary endpoints.
Results: Group 1 (control): 13male, 5female .Group2:14 male, 4female. The expulsion rate was significantly higher in group 2 than in group 1, (87/5% versus50%)(P<0.05) and Lower analgesics use was found in group 2, as well as significantly fewer hospitalization for recurrent renal colic (11/1%versus 82/4%). Both groups experienced few side effects associated with expulsive therapy.
Conclusion: In conservative management of uncomplicated distal-ureteral stones, Tamsulosin can increase stone expulsion rate and decrease need to analgesics and hospitalization.