Abstract
Backgrounds and Objectives: The mean platelet volume is an indicator for platelet disorders, which shows the rate of platelet destruction in peripheral blood, and platelet production in bone marrow. In this study we evaluated the role of (Mean Platelet Volume, MPV) in prediction of prognosis in (Idiopathic Thrombocytopenic Purpura, ITP).
Materials and Methods: Fifty patients with ITP that were admitted toTabriz Pediatric Medical Center from Oct 2003 to 2005 were studied. Chronic ITP and other purpuras were excluded .
The blood parameters including platelet count, WBC, Hb, and MPV were measured by CBC H1 and bone marrow aspiration was done by hematologist before treatment.
The patients were divided based on MPV to three groups of low (MPV<7 fl), normal
(MPV=7-11 fl) and high (MPV>11 fl) platelet volume. The patients followed in one, two weeks and one month after treatment.
Results: In this study 42 % of patients had low, 40 % normal and 18 % high MPV before treatment.
First week (P=0.004), second week (P=0.001) and one month (P=0.001) after treatment all patients in low and normal groups of MPV had good prognosis. But in the patients with high MPV, even though in first week (P=0.04) and second week (P=0.002) had favorable prognosis but after one month of treatment there was no statistically meaningful correlation between high MPV and favorable prognosis (P=0.161).
The Patients with viral infections exposure or vaccination before disease had low or normal MPV and had good prognosis (P=0.001).
Conclusion: Low or normal MPV before treatment in ITP patients and those who had history of viral infection or vaccination in last month before disease had favorable prognosis. But in patients with high MPV prognosis of diseases can not be evaluated.