Abstract
Background and Objectives: There is usually history of preceding infections 1-4 weeks before neurologic symptoms & signs of Guillain-Barre Syndrome (GBS). This study was designed to determine frequency of campylpbacter jejuni. Cytomegalovirus, Epstein-Barr virus and Mycoplasma pneumonia infections in GBS.
Material and Methods: Serologic evidences of above mentioned infections in 60 GBS patients were compared with that evidences of 60 age and sex matched controls. IgM and IgG classes of the immunoglobulins were measured using sensitive ELISA method.
Results: There were history of campylpbacter jejuni, in 45% of patients and 13.3% of controls, (P=0.001), and cytomegalovirus in 11.6% of patients and 1.7% of controls (P=0.036). History of Epstein-Barr virus in 15% of patients and 8.3% of controls (P=0.213), and Mycoplasma pneumonia in 3.3% of patients and 5% of controls (P=0.219) were detected. Children with serologic evidence of Campylpbacter jejuni infections showed axonal involvement in 65.3%.
Conclusion: Serologic evidences of preceding infections of Campylpbacter jejuni and cytomegalovirus were significantly more in GBS patients compared to controls.