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Med J Tabriz Uni Med Sciences. 2021;43(4): 368-378.
doi: 10.34172/mj.2021.063
  Abstract View: 79
  PDF Download: 15

Original Article

A Survey of interval training on the expression of ICAM, VCAM and galectin-3 proteins in the heart tissue of asthmatic rats

Masome Nobahar 1 ORCID logo, Marefat Siahkouhian 2* ORCID logo, Shadmehr Mirdar 3 ORCID logo, Lily Tapak 4 ORCID logo

1 PhD Student in Sports Physiology, Faculty of Educational Sciences and Psychology, Mohaghegh Ardabili University, Ardabil, Iran
2 Department of Sports Physiology, Faculty of Educational Sciences and Psychology, Mohaghegh Ardabili University, Ardabil, Iran
3 Department of Sports Physiology, Athletic Performance and Health Research Center, Faculty of Sports Sciences, Mazandaran University, Babolsar, Iran
4 Department of Vital Statistics, Department of Biostatistics, Faculty of Health, Non-Communicable Diseases Modeling Research Center, Hamadan University of Medical Sciences, Hamadan, Iran
*Corresponding author; E-mail: m_siahkohian@uma.ac.ir

Abstract

Background: Asthma is a heterogeneous disease whose inflammatory processes are involved in the pathophysiology of atherosclerosis and endothelial dysfunction, and increases the prevalence of cardiovascular disease. This study was designed to investigate the effect of 8 weeks of interval training on some of the effective factors in atherosclerosis in heart tissue of asthmatic rats.

Methods: In this experimental study, 15 rats were randomly divided into three groups of sham, asthma, and asthmatic-interval training. The model of asthma was induced by intraperitoneal injection of 1 ml ovalbumin for 2 weeks, and then asthmatic-interval training rats for 8 weeks participated in interval training. During the training protocol period, twice weekly intraperitoneal injections of ovalbumin 1 ml, and were placed into a glass container exposed to 5% ovalbumin spray. 48 hours after the last training session, the rats were anesthetized and their hearts were ejected. The levels of proteins expression of ICAM, VCAM, and galectin-3 were measured by immunohistochemistry, and western blotting, respectively. Data were analyzed using one-way ANOVA in SPSS at the significant level α=0.05.

Results: The results of this study showed that the expression of ICAM (P=0.001), VCAM (P=0.001), and galectin-3 (P=0.001) was significantly increased in heart tissue of asthma rats. Whereas, interval training decreased the expression of ICAM (P=0.001), VCAM (P=0.001), and galectin-3 (P=0.01) proteins in the asthmatic-interval training group compared to the asthma group.

Conclusions: It seems that, interval training is effective in preventing atherosclerosis in patients with asthma.

Keywords: Galectin 3, VCAM, ICAM
How to cite this article: Nobahar M, Siahkoohian M, Mirdar Sh, Tapak L. [A Survey of interval training on the expression of ICAM, VCAM and galectin-3 proteins in the heart tissue of asthmatic rats]. Med J Tabriz Uni Med Sciences. 2021;43(4):368-378 Persian.
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Submitted: 04 Jan 2020
ePublished: 15 Sep 2021
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