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Med J Tabriz Uni Med Sciences Health Services. 2020;42(5): 601-609.
doi: 10.34172/mj.2020.084
  Abstract View: 651
  PDF Download: 275

Original Article

The effect of eight weeks high- intensity interval training alone and combined with resistance training on miR-33b expression in PBMCs of overweight/obese women

Zhaleh Pashaei 1 ORCID logo, Afshar Jafari 2,3* ORCID logo, Mohammad reza Alivand 4 ORCID logo

1 Ph.D. Student, Department of Exercise Physiology, Faculty of Physical Education and Sport Sciences, Tabriz University, Tabriz, Iran
2 Department of Biological Sciences in Sports, Faculty of Sport Sciences and Health, Shahid Beheshti University, Tehran, Iran
3 Department of Exercise Physiology, Faculty of Physical Education and Sport Sciences, Tabriz University, Tabriz, Iran
4 Department of Medical Genetics, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
*Corresponding Author: *Corresponding author; E-mail: , Email: afshar.jafari@gmail.com

Abstract

Background: The expression of microRNAs as epigenetic regulators of lipid metabolism pathways disrupt in obese condition, in this regard miR-33b has particular importance. Therefore, the present study was conducted to determine the effect of eight-week high- intensity interval training (HIIT) alone and combined with resistance training (CHRT) on miR-33b expression in overweight/ obese middle-aged women.

Methods: Twenty-four middle-aged overweight/obese women participated in two homogeneous HIIT (5 days/week, n=12) and CHRT (3 day/week HIIT with 2 day/week resistance training, n=12) groups for eight-week. The HIIT protocol consisted of alternating bouts of high-intensity exercise at 80%–85% of VO2max with active breaks at 60% of VO2max and resistance training protocol conducted to circuit-weight training with 75-80% of 1-RM. MiR-33b expression levels were measured by real time- PCR 48h before and after the training protocols.

Results: The miR-33b expression levels were increased in both groups but was significant only in the CHRT group (6.02 fold, p=0.002). However, there was no significant difference between miR-33b expression levels in two groups.

Conclusion: According to significant effect of CHRT on miR-33b expression as epigenetic lipid metabolism indicator, CHRT protocol can be considered as a non-pharmacological method for treatment of metabolic disorders associated with obesity.


How to cite this article: Pashaei Zh, Jafari A, Alivand MR. [The effect of eight weeks high- intensity interval training alone and combined with resistance training on miR-33b expression in PBMCs of overweight/obese women]. Med J Tabriz Uni Med Sciences Health Services. 2020-2021;42(5):601-609. Persian.
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Submitted: 13 Dec 2018
ePublished: 30 Dec 2020
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