Medical Journal of Tabriz University of Medical Sciences and Health Services

Medical Journal of Tabriz University of Medical Sciences and Health Services. 2020;42(2): 152-159.
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Original Article

Serum levels of Total Sialic Acid and Lipid Profile with the Severity of the Vessel in patients with non-smoker and diabetic Coronary Artery Disease

fatemeh khaki-khatibi* ORCID logo

1 Drug Applied Research Center and Department of Clinical Biochemistry, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
*Corresponding author; E-mail:


Background: Coronary Artery Disease (CAD) is a major cause of mortality in advanced countries. Many risk factors such as high blood pressure, hyperlipidemia, diabetes, age, sex, obesity, smoking, and family history play a role in CAD. The aim of this study was to evaluate the concentration of Total Sialic Acid (TSA) and Lipid Profiles (LP) with the Severity of the Vessel in patients with non-smoker and diabetic CAD, so that by measuring these parameters, effective help for diagnosis and prevention for healthy people Prone to CAD, and also control the treatment of patients.

Methods: In this study, 200 individual including 160 patient and 40 control group were considered. All subjects were non-smokers and diabetic. Patients were divided into 4 groups according to the results of angiography: Patients with Normal angiography (n = 40) with one eclipse (n = 40), patients with double stenosis (n = 40) and patients with eclipse Three vessels (n = 40). The control group was chosen from people who had no history of CAD and other diseases. The lipid profile was measured by standard methods and serum total sialic acid was measured by ELISA method.

Result: There was no significant difference between the two groups in age and sex, but there was a significant difference in family history (p<0.05). There was a significant difference in serum glucose level between the patient and the control group (p<0.05). Serum levels of cholesterol, triglyceride, HDL and LDL were significantly higher than that of the control group (p <0.05), Also TSA serum level in the patient group was significantly higher than the control group (p<0.05).

Conclusion: Serum Total Sialic Acid level in non-smoker and diabetic CAD patients has a significant increase compared to the control group. It seems that the above biochemical parameters contribute significantly to the development and progression of atherosclerosis and CAD, by which timely measurements of these parameters in healthy individual can be helpful in preventing and improving CAD and controlling the treatment of patients.

Keywords: Total Antioxidant, MDA, Inflammatory factor, Nitric oxide, Coronary Artery Disease, Non-Smoker
How to cite this article: Khaki-Khatibi F. [Relationship between serum levels of oxidants, antioxidants, inflammatory factor and nitric oxide in diabetic and non-smoker coronary artery disease patients]. Med J Tabriz Uni Med Sciences Health Services. 2020 June- July; 42(2):152-159. Persian
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Submitted: 21 Feb 2018
ePublished: 19 May 2020
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