Medical Journal of Tabriz University of Medical Sciences and Health Services

Medical Journal of Tabriz University of Medical Sciences and Health Services. 2020;42(3): 334-339.
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Original Article

Correlation between the number of oocytes with cortisol and biochemical biomarkers of blood serum among women undergoing in vitro fertilization (IVF) treatment

behrooz niknafs 1* ORCID logo, laya farzadi 2 ORCID logo, davood gholizade eiry sofla 3 ORCID logo, marzieh niknafs 4 ORCID logo

1 Department of Anatomical Sciences, Faculty of Medical, Tabriz University of Medical Sciences, Tabriz, Iran
2 Department of Infertility, Alzahra Hospital, Tabriz University of Medical Sciences, Tabriz, Iran
3 Master of Biochemistry Department, Faculty of Medical, Tabriz University of Medical Sciences, Tabriz, Iran
4 Student of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
*Corresponding author; E-mail: niknafsbeh@yahoo.com

Abstract

Background: Secreted hormons from ovary, pituitary glands and suprarenal gland may affect the follicogenesis and the number of mature oocytes and qualified embryos of Assisted Reproductive Technology (ART). The main aim of this study was finding of correlation between the number of oocyte and embryons which gained through IVF with serum level of sex hormones and other chemical biomarkers, in addition cortisol level were detected.

Methods: Forty patients underwent infertility treatment by ART were studied the data of sex and endocrine hormones were obtained by routine laboratory techniques at follicular phase. Then serum levels of cortisol were determined at ovarian puncture day by ELISA as well as he demographic data of patients were gathered. Correlation of data determined by statistical methods.

Results: Biomarkers such as triglyceride, DHESA and testosterone were low in comparison with normal range as well as in high BMI cases. Correlation of cortisol with triglyceride and age showed significant negative correlation. As well as, oocyte number had significantly negative correlation with TSH. In spite of negative correlation of oocyte number with age, androstenedione, Testosterone, BMI, and DHESA, the number of oocyte had positive correlation with AMH.

Conclusion: Cortisol had negative correlation with Triglyceride and Age. The number of oocyte had negative correlation with TSH. They may be predictable. Correlations of other biomarkers were not seen with cortisol significantly.

Keywords: Cortisol, Oocyte number, IVF, Sex Hormones
How to cite this article: Niknafs B, Farzadi L, Gholizadeh Iyrisofla D, Niknafs M. [Correlation between the number of oocytes with cortisol and biochemical biomarkers of blood serum among women undergoing invitro fertilization (IVF) treatment]. Med J Tabriz Uni Med Sciences Health Services. 2020 August-September; 42(3):334-339. Persian.
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Submitted: 18 Oct 2018
ePublished: 18 Jul 2020
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