Medical Journal of Tabriz University of Medical Sciences and Health Services

Medical Journal of Tabriz University of Medical Sciences and Health Services. 2020;42(3): 273-280.
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Original Article

The metabolically effects of the short term endurance training among rat model of 6-hydroxydopamine Parkinson’s disease

zeinab Rezaee 1 ORCID logo, Sayed Mohammad Marandi 2* ORCID logo, Hojjatallah Alaei 3 ORCID logo, Fahimeh Esfarjani 2 ORCID logo

1 PhD student in Sports Physiology, Faculty of Physical Education and Sports Sciences, University of Isfahan, Isfahan, Iran
2 Department of Sports Physiology, Faculty of Physical Education and Sports Sciences, University of Isfahan, Isfahan, Iran
3 Department of Physiology, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
*Corresponding author; E-mail: s.m.marandi@spr.ui.ac.ir

Abstract

Background: Parkinson’s disease (PD) is known to affects the Body weight. These changes are due to multifactorial different mechanisms and training can affect on these disorders. In this study, is assessed the effect of short term endurance training on weight changes and mRNA expression of Sirtuin 1 (SIRT-1) and Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α) in rats model of 6-OHDA.

Methods: In this empirical study, Parkinson’s rats were made using stereotaxic device and by 8𝜇g injection of 6-hydroxydopamine (6-OHDA) into the Medial Forebrain Bundle (MFB). Thirty two male Wistar rats are assessed in experimental groups including: 1. Saline (Sham), 2. Saline+training, 3. 6-OHDA and 4. 6-OHDA+training (n=8). Training groups 2 weeks after the surgery started 14 consecutive days treadmill running. One month after the surgery, the rat’s weight were analyzed and using of Real Time-PCR method mRNA expression levels of the metabolically and mitochondrial factors of SIRT-1 and PGC-1α, in the striatum of rats, were measured through one way ANOVA.

Results: The 6-OHDA resulted in weight loss, significant decrease in expression of PGC-1α mRNA and a compensatory increase in SIRT-1 mRNA. However, endurance training in 6-OHDA+training group reduces these disorders, and increases mRNAs up to normal level in the Sham group (p≤0/05).

Conclusion: The endurance training can reduce disorder in body weight and metabolic factors in Parkinson’s disease.

Keywords: Parkinson Disease, Endurance Training, Mitochondria, Body Weight, 6-Hydroxydopamine
How to cite this article: Rezaee Z, Marandi S M, Alaei H, Esfarjani F. [The metabolically effects of the short term endurance training among rat model of 6-hydroxydopamine Parkinson’s disease]. Med J Tabriz Uni Med Sciences Health Services. 2020 August-September; 42(3):273-280. Persian.
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Submitted: 10 Oct 2018
ePublished: 18 Jul 2020
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