Comparison of sedative and adverse effects of hydroxyzine hydrochloride and chloral hydrate in children witch undergo echocardiography

Abstract

Background: To overcome of infants and children anxiety confronting with diagnostic and therapeutic procedures, different drugs have been used.in this study efficacy and side effects of hydroxyzine and chloral hydrate assessed during echocardiography. Methods: The study was performed on 107 patients in two groups of hydroxyzine (52 people) and chloral- hydrate (55 people).for the first group one milligram of hydroxyzine syrup and for the second group 50 gram of chloral hydrate syrup per kilogram of patient body weight was used. Results: The patients of two groups were similar about sex, age, weight and effectiveness of drugs. The volume and price of the chloral hydrate significantly was more than hydroxyzine. The time needed to begin of drug effect was similar but the duration of drug effect was significantly long about chloral hydrate. Vomiting and irritability were seen more significantly in chloral hydrate group. Conclusion: It seems that the hydroxyzine is a suitable and acceptable substitute for chloral hydrate with little side effect during non-invasive procedures such as echocardiography.