Therapeutic and prophylactic effects of chronic cerebrolysin regimen on the motor disorders of hyperglycemic rats

Abstract

Background: Diabetic hyperglycemia is one of the complication of diabetes leads to development of motor neurons and movement dysfunction. In this study, using open field test, the effect of cerebrolysin, as a compound with several neurotrophic factors, has evaluated on the hyperglycemia induced locomotor disorders. Methods: Following induction of diabetes, motor behavior of rats was assessed on days 7, 14 and 21, post diabetes induction. Results showed that on day 21, animals developed marked locomotion impairments. Diabetic animals were divided in to pretreatment and treatment groups. In both groups cerebrolysin was injected intraperitoneally for 21 consecutive days. Animal in pretreatment groups received different doses of cerebrolysin (1, 2.5 and 5 ml/kg). In treatment groups cerebrolysin was injected at the doses of 5 ml/kg. Results: Results from open field test in diabetic rats showed that, long-term administration of cerebrolysin only at the dose of 5 ml/kg improves motor disorders both in pretreatment (P<0.01) and treatment groups (P<0.05). Conclusions: According to obtained results, it seems that cerebrolysin can exhibit prophylactic and have therapeutic effects against the hyperglycemia induced locomotor complications in diabetic rats.