Effects of Combined Training on FGF23 and Some Vascular Calcification Risk Factors in Hemodialysis Patients

Abstract

Background & Objectives: Deaths from cardiovascular diseases following chronic kidney diseases are rising widely. The aim of this study was to evaluate the efficacy of a combined regular exercise during dialysis on intervening risk factors for vascular calcification diseases. Materials and Methods: Forty-five selected hemodialysis patients with a mean age of 61±9.02 years weighing 69±11.25 kg, were randomly assigned to the exercise (n=24) and control (n=21) groups. The exercise group participated in a 16-week combined exercise program. Training program included foot pedal ergometer and foot resistance exercises using weights during dialysis sessions three times a week. Parameters associated with calcification and renal function (FGF23, PTH, P and Ca) and quality of life were measured before and after the training program period. Results: Following four months combined training, parathyroid hormone and phosphorus levels significantly reduced. There were not any significant changes in blood fibroblast growth factor 23 and calcium levels. Also, exercise significantly improved the quality of life and physical functions in hemodialysis patients. Conclusion: Physical activity in hemodialysis patients is associated with changes in some factors related to vascular calcification and also improvement in the quality of life.