Gholamreza Herfehdoost
1, Minoo Sadri
2*, Narjes Pashmforosh
1, Davod zolfagari
3, Asgar Emamgholi
31 Department of Nanotechnology, Pharmacy Unite of Azad University, Tehran, Iran
2 Department of biotechnology, Malek Ashtar University of Technology, Tehran, Iran
3 Neuroscience research center, Baqiyatallah University of Medical Sciences, Tehran, Iran
Abstract
Background & Objectives: Electro spinning is a method to produce the submicron nanofiber polymer in fibers produced by this technique have a unique feature in the medical field due to their high porosity and strength, Chitosan has been used as antimicrobial and healing properties, but because of its high viscosity it is unable to form nanofibers by it self. To overcome this problem, the polymers such PEO and PVE are used. Henna extract because of its ability to Boost the growth, antibacterial and healing properties were used to form nanofibers with the above polymers. Material and Methods: The solution of chitosan, polyethylene oxide and henna in ratio ranges of 40/60 up to 10/90 were prepared. Then stabilized on the cell culture medium and then after fibroblast cells were culture on it. Results: No significant difference was detected between nanofibers cell cultured compared to controls. As healing of burn or wound is the growth of fibroblast cell and inhabitation of wound infection. Thus nanofibers could potentially be used for ulcer healing and bacterial growth prevention. Thereby the chitosan and henna is a candidate because of its anti-bacterial and boost growth boosting effect. Conclusion: As a result, Chitosan and henna as a candidate anti-bacterial and healing can be used.