Comparison of Src Expression between Aggressive and Non-Aggressive Central Giant Cell Granulomas of the Jaws

Abstract

Background and Objectives: Central giant cell granuloma is a tumor-like reactive lesion of the jaws, which is classified as aggressive and non-aggressive lesions. There are controversies about its pathogenesis, origin, histopathologic features and clinical behavior. The aim of this study was to investigate role of Src protein expression in the biologic behavior of giant cell granuloma. Materials and Methods: Paraffin-embedded tissues from 15 aggressive and 15 non-aggressive cases of central giant cell granuloma were assessed for the expression of Src using immunohistochemistry. In addition, a SID (staining-intensity distribution) score, proportion of stained cells×staining intensity, was evaluated for these lesions. Results: Although no significant difference in Src expression and SID score was recognized between the clinical forms of central giant cell granuloma (p=0.299 and p=0.900, respectively), a statistically significant correlation between them in both lesions was seen (p≤ 0.002). Conclusion: The results of this study suggest an osteoclastic origin for the giant cells and imply that Src protein expression and its intensity is not a predictor of clinical behavior of these lesions.