Logo-mj
Med J Tabriz Uni Med Sciences Health Services. 2013;34(5): 41-45.
  Abstract View: 479
  PDF Download: 91

Original Article

Counteraction Effect of Endogenous Serotonin and Cyclic Guanosine Mono Phosphate on the Anxiety Level in Mice

Siamak Shahidi, Nasrin Hashemi-Firouzi*, Minoo Mahmoodi
*Corresponding Author: Email: Email: nhashemifirozi@yahoo.com

Abstract

Background and Objectives: Selective serotonin reuptake inhibitors are widely used as anti-depressant but some adverse effects such as anxiety and sexual dysfunction have been reported. On the other hand, the effect of sildenafil, a phosphodiesterase inhibitor, which increase nitric oxide on the anxiety is controversial and there is an interaction between serotonergic systems with NO-cGMP pathway. The aim of this study was to evaluate the synergic effects of co-administration of fluoxetine and sildenafil on anxiety. Materials and Methods: In this experimental study, investigated on male mice (20-35 g) into control and experimental groups. The experimental groups received fluoxetine (20, 10 and 5 mg/kg), or a combination of fluoxetine (20, 10 and 5 mg/kg) sildenafil (10, 2 and 1 mg/kg) control group saline was injected intraperitoneally (i.p.) fifteen minutes prior placing in the Elevated plus-maze. The time spent in the open arms, number of entries in the open arms and number of total entries into the arms was measured. Results: Administration of fluoxetine decreased the time spent and number of entries into the open arms. There is no significant difference in those measurable variables in co-administration of fluoxetine and sildenafil compared with control group. Conclusion: Co-administration of fluoxetine and sildenafil has no therapeutic effect on anxiety. It seems that co-administration of sildenafil decreases the anxieogenic effect of fluoxetine.
First Name
 
Last Name
 
Email Address
 
Comments
 
Security code


Abstract View: 480

Your browser does not support the canvas element.


PDF Download: 91

Your browser does not support the canvas element.

Submitted: 28 Jan 2013
EndNote EndNote

(Enw Format - Win & Mac)

BibTeX BibTeX

(Bib Format - Win & Mac)

Bookends Bookends

(Ris Format - Mac only)

EasyBib EasyBib

(Ris Format - Win & Mac)

Medlars Medlars

(Txt Format - Win & Mac)

Mendeley Web Mendeley Web
Mendeley Mendeley

(Ris Format - Win & Mac)

Papers Papers

(Ris Format - Win & Mac)

ProCite ProCite

(Ris Format - Win & Mac)

Reference Manager Reference Manager

(Ris Format - Win only)

Refworks Refworks

(Refworks Format - Win & Mac)

Zotero Zotero

(Ris Format - Firefox Plugin)