Med J Tabriz Uni Med Sciences Health Services. 2011;33(4): 23-28.
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Original Article

Prevalence of Antibiotic Resistance and VEB-1 Type Extended-Spectrum Beta-Lactamase in Pseudomonas aeruginosa Isolates from Intensive Care Unit Patients

Yunes Khalili, Mohammad Taghi Akhi*, Reza Gotasloo, Mohammad Aghazadeh, Behrooz Naghili, Majid Pornoor
*Corresponding Author: Email: E-mail:M_T_Akhi@yahoo.com


Background and Objectives: Producing extended-spectrum beta-lactamases (ESBLs) is one of reasons for drug resistance occurrence in Pseudomonas aeruginosa isolates. The aim of the present study was to evaluate antibiotic sensitivity patterns and presence of bla VEB-1 gene in P. aerugionsa isolates collected from Imam Reza and Shahid Madani Hospitals of Tabriz, Iran. Materials and Methods: During one year period (2008-2009), 85 isolates of P. aerugionsa were collected from ICUs of Imam Reza and Shahid Madani hospitals in Tabriz and identified by conventional bacteriological tests. The antibiotic sensitivity patterns of all isolates were determined. All isolates resistant to ceftazidim were selected for determining the ESBL production by CDT method. Bla VEB-1 gene was investigated by polymerase chain reaction method. P. aerugionsa 10.2 was used as positive control strain for bla VEB-1 gene. Results: Forty three isolates (50.5%) were resistant to ceftazidim. Sixty isolates (70.5%) and 15 isolates (17.6%) were resistant to cefotaxime and imipenem, respectively. Seventy nine percent of isolates were ESBL producer. Thirteen point nine percent of the isolates contained bla VEB-1 gene. Conclusion: Considering high resistance of P. aeruginosa isolates to third and fourth generation cephalosporins, it is necessary to avoid inappropriate use of antibiotics in treatment of ESBL producing organisms.
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Submitted: 25 Oct 2011
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