Abstract
Background and Objectives: Drug interactions are accounted as one of the most important problems of Medical doctors.In this study,we investigated incidence of drug interactions in prescription of physicians and some factors which affect on drug interactions .
Materials &Methods: Primary study showed overall incidence of 7% drug interactions in Golestan province, therefore, 5300 prescriptions were gathered. After primary soft ware analysis, clinical significance of each interaction was determined. All data entered into SPSS-10 software and analysed by X 2 test
Results: Overall incidence of drug interaction was 8.7% from that 8.72% was severe, 69.3% was moderate and the rest had minor clinical significance. 79% of them were obtained with clinical importance. Prescriptions of male physicians and general practitioners had significant increase in drug interactions. Increase in mean number of drugs in each prescription caused significant increase in incidence of drug interactions.
Conclusions: There are several factors that affect the incidence of drug interactions in prescriptions of medical doctors. Continuous education of physicians may be considered to reduce it.