Abstract
Backgrounds and objectives: Atopic dermatitis is a common chronic skin disease which causes pruritus and relapsing eczematous lesion, leading to major problems in private and social life. Vitamin E has few side effects ( comparing to common treatments), for this reason Vitamin E has recently been recommended as a new treatment.
Materials & Methods: For this clinical trial 100 patients with Atopic dermatitis were visited in Skin clinic of Tabriz Sina hospital. These patients were divided into two groups by simple randomization. In group 1, patients took vitamin E (400 Iu/day) in group 2 took topical corticosteroid and oral Antihistamines. Patients were followed up for 8 months.
Results: The results of the treatment were positive in the 66% of the patients in group I and 62 % of the patients in group II. There is no statistical difference in response to therapy in both groups ( P> 0/05), but satisfaction is very high in patients received vitamin E. There is significantly inverse relationship between age and response to therapy in patients who took vitamin E .In this study no side effects reported from vitamin E .
Conclusion: According to this trial, vitamin E may affect the same as common treatment with topical corticosteroid and oral Antihistamines in improving signs & symptoms of Atopic dermatitis and quality of life. By considering the lack of side effects of therapeutic dose of vitamin E, it can be a suitable therapy for Atopic dermatitis.